MTCH2

MTCH2
Identifiers
Aliases	MTCH2, MIMP, SLC25A50, HSPC032, mitochondrial carrier 2
External IDs	OMIM: 613221; MGI: 1929260; HomoloGene: 8645; GeneCards: MTCH2; OMA:MTCH2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,642,607 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	90,697,154 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; mucosa of transverse colon; ; rectum; ; right lobe of liver; ; duodenum; ; stromal cell of endometrium; ; islet of Langerhans; ; gastrocnemius muscle; ; human kidney;
	Top expressed in
	spermatid; ; spermatocyte; ; testicle; ; duodenum; ; jejunum; ; colon; ; right kidney; ; proximal tubule; ; ileum; ; white adipose tissue;
	More reference expression data
	n/a
Orthologs
	23788
	56428
	ENSG00000109919; ENSG00000285121
	ENSMUSG00000027282
	Q9Y6C9
	Q791V5
	NM_014342; NM_001317231; NM_001317232; NM_001317233
	NM_019758; NM_001317241; NM_001317242; NM_001317243; NM_001317244
	NP_001304160; NP_001304161; NP_001304162; NP_055157
	NP_001304170; NP_001304171; NP_001304172; NP_001304173; NP_062732
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.^[5]^[6]^[7]^[8]

Clinical significance

Variants of the MTCH2 gene may be associated with obesity.^[9]

References

^ ^a ^b ^c ENSG00000285121 GRCh38: Ensembl release 89: ENSG00000109919, ENSG00000285121 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027282 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha". Mol. Cell. Biol. 25 (11): 4579–90. doi:10.1128/MCB.25.11.4579-4590.2005. PMC 1140633. PMID 15899861.
^ Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". J. Bioenerg. Biomembr. 37 (3): 113–9. doi:10.1007/s10863-005-6222-3. PMID 16167168.
^ Schwarz M, Andrade-Navarro MA, Gross A (May 2007). "Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?". Apoptosis. 12 (5): 869–76. doi:10.1007/s10495-007-0748-2. PMID 17453157.
^ Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, Li H, Leung CH, Zhu Y, Wei CL, Hooi SC, Miller L, Tan P (2008). Chang HY (ed.). "A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers". PLoS Genet. 4 (7): e1000129. doi:10.1371/journal.pgen.1000129. PMC 2444049. PMID 18636107. {{cite journal}}: Unknown parameter |editorlink1= ignored (|editor-link1= suggested) (help)CS1 maint: unflagged free DOI (link)
^ Renström F, Payne F, Nordström A, et al. (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.

Yerushalmi GM, Leibowitz-Amit R, Shaharabany M, Tsarfaty I (2002). "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization". Neoplasia. 4 (6): 510–22. doi:10.1038/sj.neo.7900272. PMC 1503665. PMID 12407445.
Haupt A, Thamer C, Heni M, et al. (2009). "Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study". Obesity (Silver Spring). 18 (6): HASH(0x2a07f00). doi:10.1038/oby.2009.413. PMID 19910938.
Albers M, Kranz H, Kober I, et al. (2005). "Automated yeast two-hybrid screening for nuclear receptor-interacting proteins". Mol. Cell. Proteomics. 4 (2): 205–13. doi:10.1074/mcp.M400169-MCP200. PMID 15604093.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Willer CJ, Speliotes EK, Loos RJ, et al. (2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 25–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261.
Li S, Zhao JH, Luan J, et al. (2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies". Am. J. Clin. Nutr. 91 (1): 184–90. doi:10.3945/ajcn.2009.28403. PMID 19812171.
Brandys MK, van Elburg AA, Loos RJ, et al. (2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang QH, Ye M, Wu XY, et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Bauer F, Elbers CC, Adan RA, et al. (2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference". Am. J. Clin. Nutr. 90 (4): 951–9. doi:10.3945/ajcn.2009.27781. PMID 19692490.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
He M, Cornelis MC, Franks PW, et al. (2010). "Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus". Arterioscler. Thromb. Vasc. Biol. 30 (2): 327–32. doi:10.1161/ATVBAHA.109.196196. PMC 3061473. PMID 19910641.
Hotta K, Nakamura M, Nakamura T, et al. (2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population". J. Hum. Genet. 54 (12): 727–31. doi:10.1038/jhg.2009.106. PMID 19851340.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000285121 GRCh38: Ensembl release 89: ENSG00000109919, ENSG00000285121 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027282 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15899861-5] Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha". Mol. Cell. Biol. 25 (11): 4579–90. doi:10.1128/MCB.25.11.4579-4590.2005. PMC 1140633. PMID 15899861.

[pmid16167168-6] Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". J. Bioenerg. Biomembr. 37 (3): 113–9. doi:10.1007/s10863-005-6222-3. PMID 16167168.

[pmid17453157-7] Schwarz M, Andrade-Navarro MA, Gross A (May 2007). "Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?". Apoptosis. 12 (5): 869–76. doi:10.1007/s10495-007-0748-2. PMID 17453157.

[pmid18636107-8] Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, Li H, Leung CH, Zhu Y, Wei CL, Hooi SC, Miller L, Tan P (2008). Chang HY (ed.). "A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers". PLoS Genet. 4 (7): e1000129. doi:10.1371/journal.pgen.1000129. PMC 2444049. PMID 18636107. {{cite journal}}: Unknown parameter |editorlink1= ignored (|editor-link1= suggested) (help)CS1 maint: unflagged free DOI (link)

[pmid19164386-9] Renström F, Payne F, Nordström A, et al. (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.

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MTCH2

Clinical significance

See also

References

Further reading