Unconventional myosin-VI

MYO6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2N11, 2N13, 2N0Z, 2N10, 2N12
Identifiers
Aliases	MYO6, DFNA22, DFNB37, myosin VI, Myo6-008, Myo6-007
External IDs	OMIM: 600970; MGI: 104785; HomoloGene: 56417; GeneCards: MYO6; OMA:MYO6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q14.1 Start 75,749,201 bp End 75,919,537 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 E1|9 43.98 cM Start 80,072,313 bp End 80,219,011 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid internal globus pallidus corpus callosum sural nerve external globus pallidus pancreatic ductal cell inferior ganglion of vagus nerve pars reticulata subthalamic nucleus renal medulla Top expressed in olfactory epithelium neural layer of retina yolk sac right kidney human kidney utricle epithelium of small intestine ileum Ileal epithelium vestibular sensory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal motor activity actin filament binding ATP binding calmodulin binding protein binding minus-end directed microfilament motor activity ADP binding actin binding nucleotide binding cadherin binding identical protein binding Cellular component myosin complex nucleus intracellular membrane-bounded organelle cell projection ruffle membrane RNA polymerase II, holoenzyme nucleoplasm lysosomal membrane perinuclear region of cytoplasm clathrin-coated endocytic vesicle apical part of cell clathrin-coated vesicle membrane ruffle cytosol extracellular exosome membrane clathrin-coated pit filamentous actin plasma membrane nuclear membrane cytoplasm cell cortex microvillus Golgi apparatus unconventional myosin complex endocytic vesicle cytoplasmic vesicle actin filament protein-containing complex clathrin-coated vesicle filopodium Biological process intracellular protein transport actin filament-based movement regulation of secretion hearing positive regulation of transcription by RNA polymerase II protein transport endocytosis DNA damage response, signal transduction by p53 class mediator transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4646 17920 Ensembl ENSG00000196586 ENSMUSG00000033577 UniProt Q9UM54 Q64331 RefSeq (mRNA) NM_001300899 NM_004999 NM_001368136 NM_001368137 NM_001368138 NM_001368139 NM_001368140 NM_001368865 NM_001368866 NM_001039546 NM_008662 RefSeq (protein) NP_001287828 NP_004990 NP_001355065 NP_001355066 NP_001355067 NP_001355068 NP_001355069 NP_001355794 NP_001355795 n/a Location (UCSC) Chr 6: 75.75 – 75.92 Mb Chr 9: 80.07 – 80.22 Mb PubMed search
Wikidata
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Myosin VI, also known as MYO6, is a protein. It has been found in humans, mice, fruit flies (Drosophila melanogaster), and nematodes (Caenorhabditis elegans).

Function

Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins.[supplied by OMIM]

Interactions

MYO6 has been shown to interact with GIPC1 and DAB2.

Further reading

• Buss F, Luzio JP, Kendrick-Jones J (Nov 2001). "Myosin VI, a new force in clathrin mediated endocytosis". FEBS Letters. 508 (3): 295–9. doi:10.1016/S0014-5793(01)03065-4. PMID 11728438.
• Hasson T (Sep 2003). "Myosin VI: two distinct roles in endocytosis". Journal of Cell Science. 116 (Pt 17): 3453–61. doi:10.1242/jcs.00669. PMID 12893809.
• Avraham KB, Hasson T, Steel KP, Kingsley DM, Russell LB, Mooseker MS, Copeland NG, Jenkins NA (Dec 1995). "The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells". Nature Genetics. 11 (4): 369–75. doi:10.1038/ng1295-369. PMID 7493015.
• Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (Jul 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6549–53. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Avraham KB, Hasson T, Sobe T, Balsara B, Testa JR, Skvorak AB, Morton CC, Copeland NG, Jenkins NA (Aug 1997). "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice". Human Molecular Genetics. 6 (8): 1225–31. doi:10.1093/hmg/6.8.1225. PMID 9259267.
• Buss F, Kendrick-Jones J, Lionne C, Knight AE, Côté GP, Paul Luzio J (Dec 1998). "The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation". The Journal of Cell Biology. 143 (6): 1535–45. doi:10.1083/jcb.143.6.1535. PMC 2132970. PMID 9852149.
• Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA, Sweeney HL (Sep 1999). "Myosin VI is an actin-based motor that moves backwards". Nature. 401 (6752): 505–8. doi:10.1038/46835. PMID 10519557.
• Buss F, Arden SD, Lindsay M, Luzio JP, Kendrick-Jones J (Jul 2001). "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis". The EMBO Journal. 20 (14): 3676–84. doi:10.1093/emboj/20.14.3676. PMC 125554. PMID 11447109.
• Melchionda S, Ahituv N, Bisceglia L, Sobe T, Glaser F, Rabionet R, Arbones ML, Notarangelo A, Di Iorio E, Carella M, Zelante L, Estivill X, Avraham KB, Gasparini P (Sep 2001). "MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss". American Journal of Human Genetics. 69 (3): 635–40. doi:10.1086/323156. PMC 1235492. PMID 11468689.
• Yoshimura M, Homma K, Saito J, Inoue A, Ikebe R, Ikebe M (Oct 2001). "Dual regulation of mammalian myosin VI motor function". The Journal of Biological Chemistry. 276 (43): 39600–7. doi:10.1074/jbc.M105080200. PMID 11517222.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Rock RS, Rice SE, Wells AL, Purcell TJ, Spudich JA, Sweeney HL (Nov 2001). "Myosin VI is a processive motor with a large step size". Proceedings of the National Academy of Sciences of the United States of America. 98 (24): 13655–9. doi:10.1073/pnas.191512398. PMC 61096. PMID 11707568.
• Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.
• Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127.
• Wu H, Nash JE, Zamorano P, Garner CC (Aug 2002). "Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking". The Journal of Biological Chemistry. 277 (34): 30928–34. doi:10.1074/jbc.M203735200. PMID 12050163.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Ahmed ZM, Morell RJ, Riazuddin S, Gropman A, Shaukat S, Ahmad MM, Mohiddin SA, Fananapazir L, Caruso RC, Husnain T, Khan SN, Riazuddin S, Griffith AJ, Friedman TB, Wilcox ER (May 2003). "Mutations of MYO6 are associated with recessive deafness, DFNB37". American Journal of Human Genetics. 72 (5): 1315–22. doi:10.1086/375122. PMC 1180285. PMID 12687499.
• Aschenbrenner L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Molecular Biology of the Cell. 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860.