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Michael Clayton may refer to:
- Michael Clayton (American football) (born 1982), former American football wide receiver
- Michael Clayton (golfer) (born 1957), Australian professional golfer
- Michael P. Clayton (born 1959), American businessman
- Michael Clayton (film), a 2007 film starring George Clooney
- Michael Clayton (soundtrack), the soundtrack for the film
| disambiguation page lists articles associated with the title Michael Clayton.
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