Mucin 5AC

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Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesMUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDsMGI: 104697 HomoloGene: 137237 GeneCards: MUC5AC
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for MUC5AC
Genomic location for MUC5AC
Band11p15.5Start1,157,953 bp[1]
End1,201,138 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 11: 1.16 – 1.2 MbChr 7: 141.79 – 141.82 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene.[5][6][7]

Clinical relevance[edit]

This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).[8]


  1. ^ a b c ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037974 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. PMC 1136451. PMID 7826332.
  6. ^ van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
  7. ^ "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
  8. ^ Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012). "Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers". BMC Med. Genom. 5 (1): 21. doi:10.1186/1755-8794-5-21. PMC 3443416. PMID 22676183.

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Mucin-5AC