Muhammad al-Nafs al-Zakiyya
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Muhammad ibn Abdullah ibn al-Hasan al-Muthana ibn al-Hasan al-Mujtaba ibn 'Ali ibn Abi Talib or Muhammad al-Nafs al-Zakiyya (Arabic: محمد بن عبد الله بن الحسن بن الحسن بن علي الملقَّب النفس الزكية, "The Pure Soul") was a descendant of Muhammad through his daughter Fatimah. Known for his commanding oratory skills, amiable demeanor, and impressive build, he led the Alid Revolt (762–763) in Medina, a failed rebellion, against the second Abbasid Caliph, Al-Mansur. His followers deserted him and he was left with few hundred of his soldiers against large Abbasid force under Isa ibn Musa, and he was martyred on December 6, 762 CE (145 AH).
Initially, he hoped to rebel against Umayyad rule, when the children of Hashim paid their allegiance to him at Abwa. Among them were Ibrahim al-Imam, As-Saffah and Al-Mansur. But it soon became clear that Abbasid rule was established, so those who had paid allegiance to him deserted him, and another group of Shiites flocked around him.
Muhammad was an inspirational figure to many throughout the caliphate who believed that he was destined for glory due to his ancestry. For years he disguised himself and traveled stealthily, since his professed relationship to the Prophet meant that he posed a threat to the established political order. He was eventually able to amass a sizable but ragtag army and seize the city of Medina. He then left Medina in the year 145 A.H and took over Mecca and Yemen (only to be killed in Medina a few months later).
His revolt in 762–763
Medina was an exceptionally poor place for any large-scale insurrection due to its dependence on other provinces for goods, and his motley army of devotees were no match for the Caliph's imperial soldiers. Despite the advantage held by the Abbasid troops, Muhammad refused to step down in the hours before battle, utilizing the historic trenches dug by the Prophet to fortify the city decades earlier.