NANS

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NANS
Protein NANS PDB 1wvo.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NANS, HEL-S-100, SAS, N-acetylneuraminate synthase, SEMDG, SEMDCG
External IDs MGI: 2149820 HomoloGene: 10343 GeneCards: NANS
EC number 2.5.1.57
RNA expression pattern
PBB GE NANS 218189 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018946

NM_053179

RefSeq (protein)

NP_061819

NP_444409

Location (UCSC) Chr 9: 98.06 – 98.08 Mb Chr 4: 46.49 – 46.5 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.[3][4]

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. However, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ (Jul 2000). "Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability". J Biol Chem. 275 (23): 17869–77. doi:10.1074/jbc.M000217200. PMID 10749855. 
  4. ^ a b "Entrez Gene: NANS N-acetylneuraminic acid synthase (sialic acid synthase)". 

Further reading[edit]