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Enzyme
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene .[ 5] [ 6]
3'-phosphoadenylyl sulfate + α-D -glucosaminyl-[heparan sulfate ](n ) = adenosine 3',5'-bisphosphate + 2 H+ + N -sulfo-α-D -glucosaminyl-[heparan sulfate](n ) [ 7]
This is a step in the production of heparin .[ 7]
Clinical significance [ edit ] Mutations in NDST3 have been linked to schizophrenia .[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000164100 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027977 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Aikawa J, Esko JD (Mar 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family" . J Biol Chem . 274 (5): 2690–5. doi :10.1074/jbc.274.5.2690 PMID 9915799 . ^ "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3" .^ a b "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein" . www.uniprot.org . Retrieved 2020-01-15 .^ Zhang, C; Lu, W; Wang, Z; Ni, J; Zhang, J; Tang, W; Fang, Y (January 2016). "A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese" . Translational Psychiatry . 6 (1): e701. doi :10.1038/tp.2015.199 . ISSN 2158-3188 . PMC 5068873 PMID 26731438 .
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