NEIL3

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NEIL3
Identifiers
Aliases NEIL3, FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3, nei like DNA glycosylase 3
External IDs MGI: 2384588 HomoloGene: 10094 GeneCards: NEIL3
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018248

NM_146208

RefSeq (protein)

NP_060718.2

NP_666320.1

Location (UCSC) Chr 4: 177.31 – 177.36 Mb Chr 8: 53.59 – 53.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene.[3]

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: Nei endonuclease VIII-like 3 (E. coli)". 
  4. ^ Bandaru V, Sunkara S, Wallace SS, Bond JP (July 2002). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII". DNA Repair (Amst.). 1 (7): 517–29. doi:10.1016/S1568-7864(02)00036-8. PMID 12509226.