NELL1

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NELL1
Identifiers
AliasesNELL1, IDH3GL, NRP1, neural EGFL like 1
External IDsOMIM: 602319 MGI: 2443902 HomoloGene: 4486 GeneCards: NELL1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NELL1
Genomic location for NELL1
Band11p15.1Start20,669,551 bp[1]
End21,575,681 bp[1]
RNA expression pattern
PBB GE NELL1 206089 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001288713
NM_001288714
NM_006157
NM_201551

NM_001037906

RefSeq (protein)

NP_001275642
NP_001275643
NP_006148
NP_963845

NP_001032995

Location (UCSC)Chr 11: 20.67 – 21.58 MbChr 7: 49.97 – 50.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein kinase C-binding protein NELL1 also known as NEL-like protein 1 (NELL1) or Nel-related protein 1 (NRP1) is a protein that in humans is encoded by the NELL1 gene.[5][6][7]

Function[edit]

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full-length sequence has not been determined.[6]

Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of stem cells.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165973 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055409 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Watanabe TK, Katagiri T, Suzuki M, Shimizu F, Fujiwara T, Kanemoto N, Nakamura Y, Hirai Y, Maekawa H, Takahashi E (Mar 1997). "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats". Genomics. 38 (3): 273–6. doi:10.1006/geno.1996.0628. PMID 8975702.
  6. ^ a b "Entrez Gene: NELL1 NEL-like 1 (chicken)".
  7. ^ a b "Study reveals bone-building protein's impact on bone stem cells".

Further reading[edit]