Jump to content

NKTR

From Wikipedia, the free encyclopedia
NKTR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNKTR, p104, natural killer cell triggering receptor
External IDsOMIM: 161565; MGI: 97346; HomoloGene: 122148; GeneCards: NKTR; OMA:NKTR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001012651
NM_005385
NM_001349124
NM_001349125
NM_001349126

NM_010918

RefSeq (protein)

NP_005376
NP_001336053
NP_001336054
NP_001336055

NP_035048

Location (UCSC)Chr 3: 42.6 – 42.65 MbChr 9: 121.72 – 121.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NK-tumor recognition protein is a protein that in humans is encoded by the NKTR gene.[5][6][7]

This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114857Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032525Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Young HA, Jenkins NA, Copeland NG, Simek S, Lerman MI, Zbar B, Glenn G, Ortaldo JR, Anderson SK (Jul 1993). "Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9". Genomics. 16 (2): 548–549. doi:10.1006/geno.1993.1229. PMID 8314596.
  6. ^ Chambers CA, Gallinger S, Anderson SK, Giardina S, Ortaldo JR, Hozumi N, Roder J (May 1994). "Expression of the NK-TR gene is required for NK-like activity in human T cells". J Immunol. 152 (6): 2669–74. doi:10.4049/jimmunol.152.6.2669. PMID 8144875. S2CID 20265645.
  7. ^ a b "Entrez Gene: NKTR natural killer-tumor recognition sequence".

Further reading

[edit]