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HCV genome

Nonstructural protein 3 (NS3), also known as p-70, is a viral nonstructural protein that is 70 kDa cleavage product of the hepatitis C virus polyprotein. It acts as a serine protease.[1][2] C-terminal two thirds of the protein also acts as helicase and nucleoside triphosphatase.[3] First (N-terminal) 180 aminoacids of NS3 has additional role as cofactor domains for NS2 protein[4].

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  1. ^ Hijikata, M. et al. (1993) Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Proc. Natl. Acad. Sci. USA. 90, 10773-10777.
  2. ^ Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target July 23, 2010, The Journal of Biological Chemistry, 285, 22725-22731. doi: 10.1074/jbc.R110.125294
  3. ^ Stimulation of Hepatitis C Virus (HCV) Nonstructural Protein 3 (NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase / J. Virol. July 2005 vol. 79 no. 14 8687-8697
  4. ^ Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3. / Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5342-7. doi: 10.1073/pnas.0810950106.
  5. ^ "NS3/4A Protease Inhibitors - DrugBank".

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