Nucleoporin 50

From Wikipedia, the free encyclopedia
  (Redirected from NUP50)
Jump to: navigation, search
Available structures
PDB Ortholog search: PDBe RCSB
Aliases NUP50, NPAP60, NPAP60L, nucleoporin 50kDa
External IDs MGI: 1351502 HomoloGene: 5190 GeneCards: 10762
RNA expression pattern
PBB GE NUP50 213682 at tn.png

PBB GE NUP50 218293 x at tn.png

PBB GE NUP50 218294 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 22: 45.16 – 45.19 Mb Chr 15: 84.92 – 84.94 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.[3][4]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.[4]


NUP50 has been shown to interact with KPNB1[5] and CDKN1B.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Trichet V, Shkolny D, Dunham I, Beare D, McDermid HE (October 1999). "Mapping and complex expression pattern of the human NPAP60L nucleoporin gene". Cytogenet Cell Genet. 85 (3–4): 221–6. doi:10.1159/000015297. PMID 10449902. 
  4. ^ a b "Entrez Gene: NUP50 nucleoporin 50kDa". 
  5. ^ Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell. United States. 110 (3): 349–60. doi:10.1016/S0092-8674(02)00836-X. ISSN 0092-8674. PMID 12176322. 
  6. ^ Smitherman, M; Lee K; Swanger J; Kapur R; Clurman B E (August 2000). "Characterization and Targeted Disruption of Murine Nup50, a p27Kip1-Interacting Component of the Nuclear Pore Complex". Mol. Cell. Biol. UNITED STATES. 20 (15): 5631–42. doi:10.1128/MCB.20.15.5631-5642.2000. ISSN 0270-7306. PMC 86029free to read. PMID 10891500. 

Further reading[edit]