NUP98

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NUP98
Protein NUP98 PDB 1ko6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NUP98, ADIR2, NUP196, NUP96, nucleoporin 98kDa, nucleoporin 98
External IDs MGI: 109404 HomoloGene: 35472 GeneCards: NUP98
RNA expression pattern
PBB GE NUP98 203194 s at fs.png

PBB GE NUP98 203195 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005387
NM_016320
NM_139131
NM_139132

NM_001287164
NM_001287165
NM_001287166
NM_001287167
NM_022979

RefSeq (protein)

NP_005378
NP_057404
NP_624357
NP_624358

Location (UCSC) Chr 11: 3.67 – 3.8 Mb Chr 7: 102.12 – 102.21 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.[3]

Function[edit]

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.[4]

Interactions[edit]

NUP98 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M (June 1997). "The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10". Blood. 89 (11): 3936–44. PMID 9166830. 
  4. ^ "Entrez Gene: NUP98 nucleoporin 98kDa". 
  5. ^ Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van Deursen JM (January 1999). "CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity". Mol. Cell. Biol. 19 (1): 764–76. doi:10.1128/mcb.19.1.764. PMC 83933Freely accessible. PMID 9858599. 
  6. ^ Moroianu J, Blobel G, Radu A (September 1997). "RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9699–704. doi:10.1073/pnas.94.18.9699. PMC 23253Freely accessible. PMID 9275187. 
  7. ^ Bonifaci N, Moroianu J, Radu A, Blobel G (May 1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5055–60. doi:10.1073/pnas.94.10.5055. PMC 24630Freely accessible. PMID 9144189. 
  8. ^ Griffis ER, Xu S, Powers MA (February 2003). "Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes". Mol. Biol. Cell. 14 (2): 600–10. doi:10.1091/mbc.E02-09-0582. PMC 149995Freely accessible. PMID 12589057. 
  9. ^ Pritchard CE, Fornerod M, Kasper LH, van Deursen JM (April 1999). "RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains". J. Cell Biol. 145 (2): 237–54. doi:10.1083/jcb.145.2.237. PMC 2133102Freely accessible. PMID 10209021. 
  10. ^ Fontoura BM, Blobel G, Yaseen NR (October 2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". J. Biol. Chem. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. PMID 10875935. 

Further reading[edit]