OSTbeta

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SLC51B
Identifiers
Aliases SLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit
External IDs MGI: 3582052 HomoloGene: 18721 GeneCards: SLC51B
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for SLC51B
Genomic location for SLC51B
Band 15q22.31 Start 65,045,370 bp[1]
End 65,053,396 bp[1]
RNA expression pattern
PBB GE OSTbeta gnf1h06426 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178859

NM_178933

RefSeq (protein)

NP_849190

NP_849264

Location (UCSC) Chr 15: 65.05 – 65.05 Mb Chr 9: 65.41 – 65.42 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.[5][6]

Function[edit]

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[6][7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[7] The heterodimer furthermore is essential for intestinal bile acid transport.[8]

OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186198 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053862 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: OSTbeta organic solute transporter beta". 
  6. ^ a b c Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432. 
  7. ^ a b Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727Freely accessible. PMID 15563450. 
  8. ^ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. doi:10.1073/pnas.0712328105. PMC 2268840Freely accessible. PMID 18292224. 

Further reading[edit]