OSTbeta

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SLC51B
Identifiers
Aliases SLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit
External IDs MGI: 3582052 HomoloGene: 18721 GeneCards: SLC51B
RNA expression pattern
PBB GE OSTbeta gnf1h06426 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178859

NM_178933

RefSeq (protein)

NP_849190

NP_849264

Location (UCSC) Chr 15: 65.05 – 65.05 Mb Chr 9: 65.41 – 65.42 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.[3][4]

Function[edit]

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[4][5] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[5] The heterodimer furthermore is essential for intestinal bile acid transport.[6]

OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: OSTbeta organic solute transporter beta". 
  4. ^ a b c Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. PMID 12719432. doi:10.1074/jbc.M301106200. 
  5. ^ a b Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. PMC 1224727Freely accessible. PMID 15563450. doi:10.1074/jbc.M412752200. 
  6. ^ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. PMC 2268840Freely accessible. PMID 18292224. doi:10.1073/pnas.0712328105. 

Further reading[edit]