PADI4

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
PADI4
Protein PADI4 PDB 1wd8.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPADI4, PAD, PAD4, PADI5, PDI4, PDI5, peptidyl arginine deiminase 4
External IDsMGI: 1338898 HomoloGene: 7883 GeneCards: PADI4
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PADI4
Genomic location for PADI4
Band1p36.13Start17,308,195 bp[1]
End17,364,004 bp[1]
RNA expression pattern
PBB GE PADI4 211413 s at fs.png

PBB GE PADI4 211412 at fs.png

PBB GE PADI4 220001 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012387

NM_011061

RefSeq (protein)

NP_036519

NP_035191

Location (UCSC)Chr 1: 17.31 – 17.36 MbChr 4: 140.75 – 140.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peptidyl arginine deiminase, type IV, also known as PADI4, is a human protein which in humans is encoded by the PADI4 gene.[5][6]

Molecular biology[edit]

The human gene is found on the short arm of Chromosome 1 near the telomere (1p36.13). It is located on the Watson (plus) strand and is 55,806 bases long. The protein is 663 amino acids long with a molecular weight of 74,095 Da.[5]

Function[edit]

This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.[6] PADI4 plays a role in the epigenetics, the deimination of arginines on histones 3 and 4 can act antagonistically to arginine methylation (Chromatin modifications and their function, Kouzarides 2007, Cell, review)

The protein may be found in oligomers and binds 5 calcium ions per subunit. It catalyses the reaction:

  • Protein L-arginine + H2O = protein L-citrulline + NH3

Subcellular and tissue distribution[edit]

It is normally found in the cytoplasm, nucleus and in cytoplasmic granules of eosinophils and neutrophils. It is not expressed in peripheral monocytes or lymphocytes. It is also expressed in rheumatoid arthritis synovial tissues.

References[edit]

  1. ^ a b c ENSG00000159339 GRCh38: Ensembl release 89: ENSG00000280908, ENSG00000159339 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025330 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b Nakashima K, Hagiwara T, Ishigami A, Nagata S, Asaga H, Kuramoto M, Senshu T, Yamada M (September 1999). "Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3)". J. Biol. Chem. 274 (39): 27786–92. doi:10.1074/jbc.274.39.27786. PMID 10488123.
  6. ^ a b "Entrez Gene: PADI4 peptidyl arginine deiminase, type IV".

Further reading[edit]