PANK1

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PANK1
Protein PANK1 PDB 2i7n.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPANK1, PANK, pantothenate kinase 1
External IDsMGI: 1922985 HomoloGene: 56979 GeneCards: PANK1
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PANK1
Genomic location for PANK1
Band10q23.31Start89,579,497 bp[1]
End89,645,572 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138316
NM_148977
NM_148978

NM_001114339
NM_023792

RefSeq (protein)

NP_612189
NP_683878
NP_683879

NP_001107811
NP_076281

Location (UCSC)Chr 10: 89.58 – 89.65 MbChr 19: 34.81 – 34.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.[5]

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152782 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033610 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: PANK1 pantothenate kinase 1".

Further reading[edit]