PCBP4

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PCBP4
Identifiers
AliasesPCBP4, CBP, LIP4, MCG10, poly(rC) binding protein 4
External IDsMGI: 1890471 HomoloGene: 56926 GeneCards: PCBP4
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PCBP4
Genomic location for PCBP4
Band3p21.2Start51,957,454 bp[1]
End51,974,016 bp[1]
RNA expression pattern
PBB GE PCBP4 209361 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001174100
NM_020418
NM_033008
NM_033009
NM_033010

NM_021567

RefSeq (protein)

NP_001167571
NP_065151
NP_127501
NP_127503
NP_001350814

NP_067542

Location (UCSC)Chr 3: 51.96 – 51.97 MbChr 9: 106.45 – 106.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.[5][6]

This gene encodes a member of the KH domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090097 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023495 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Makeyev AV, Liebhaber SA (Sep 2000). "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins". Genomics. 67 (3): 301–16. doi:10.1006/geno.2000.6244. PMID 10936052.
  6. ^ a b "Entrez Gene: PCBP4 poly(rC) binding protein 4".

Further reading[edit]