PCDH8

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PCDH8
Identifiers
Aliases PCDH8, ARCADLIN, PAPC, protocadherin 8
External IDs MGI: 1306800 HomoloGene: 1943 GeneCards: PCDH8
RNA expression pattern
PBB GE PCDH8 206935 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032949
NM_002590

NM_001042726
NM_021543

RefSeq (protein)

NP_002581
NP_116567

NP_001036191.1
NP_067518.2
NP_001036191
NP_067518

Location (UCSC) Chr 13: 52.84 – 52.85 Mb Chr 14: 79.77 – 79.77 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.[3][4][5]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Strehl S, Glatt K, Liu QM, Glatt H, Lalande M (Dec 1998). "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14". Genomics. 53 (1): 81–9. doi:10.1006/geno.1998.5467. PMID 9787079. 
  4. ^ Strehl S, LaSalle JM, Lalande M (Oct 1997). "High-resolution analysis of DNA replication domain organization across an R/G-band boundary". Mol Cell Biol. 17 (10): 6157–66. PMC 232466Freely accessible. PMID 9315676. 
  5. ^ a b "Entrez Gene: PCDH8 protocadherin 8". 

Further reading[edit]