From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein PCDHA3 PDB 1wuz.png
Aliases PCDHA3, PCDH-ALPHA3, protocadherin alpha 3
External IDs MGI: 2447313 HomoloGene: 129613 GeneCards: PCDHA3
RNA expression pattern
PBB GE PCDHA3 210572 at fs.png

PBB GE PCDHA3 211870 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 140.8 – 141.01 Mb Chr 18: 36.95 – 37.19 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Protocadherin alpha-3 is a protein that in humans is encoded by the PCDHA3 gene.[3][4]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[4]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  4. ^ a b "Entrez Gene: PCDHA3 protocadherin alpha 3". 

Further reading[edit]