PCLKC

CDHR2
Identifiers
Aliases	CDHR2, PCDH24, PCLKC, cadherin related family member 2, PCLCK
External IDs	MGI: 2687323; HomoloGene: 134510; GeneCards: CDHR2; OMA:CDHR2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	176,595,974 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	54,884,475 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of ileum; ; duodenum; ; mucosa of transverse colon; ; rectum; ; left testis; ; right lobe of liver; ; sperm; ; right testis; ; mucosa of sigmoid colon;
	Top expressed in
	jejunum; ; ileum; ; duodenum; ; epithelium of small intestine; ; colon; ; left colon; ; Paneth cell; ; yolk sac; ; right kidney; ; human kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; cell adhesion molecule binding;
Cellular component	integral component of membrane; spanning component of plasma membrane; brush border membrane; cell junction; plasma membrane; extracellular exosome; apical plasma membrane; brush border; membrane; cell projection; microvillus membrane;
Biological process	cell adhesion; epithelial cell differentiation; regulation of microvillus length; negative regulation of cell growth involved in contact inhibition; homophilic cell adhesion via plasma membrane adhesion molecules; cell-cell adhesion mediated by cadherin; intermicrovillar adhesion; cell differentiation; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	54825
	268663
	ENSG00000074276
	ENSMUSG00000034918
	Q9BYE9
	E9Q7P9
	NM_001171976; NM_017675
	NM_001033364
	NP_001165447; NP_060145
	NP_001028536
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-24 is a protein that in humans is encoded by the PCDH24 gene.^[5]^[6]^[7]

Interactions

PCLKC has been shown to interact with MAST2.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074276 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034918 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
^ ^a ^b Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (Jul 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis. 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771.
^ "Entrez Gene: PCLKC protocadherin LKC".

Yang LY, Wang W, Peng JX, et al. (2005). "Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma". World J. Gastroenterol. 10 (24): 3569–73. doi:10.3748/wjg.v10.i24.3569. PMC 4611994. PMID 15534908.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000074276 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034918 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11082270-5] Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.

[pmid12117771-6] Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (Jul 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis. 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771.

[entrez-7] "Entrez Gene: PCLKC protocadherin LKC".

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Interactions

References

Further reading