PCLKC

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CDHR2
Identifiers
Aliases CDHR2, PCDH24, PCLKC, cadherin related family member 2
External IDs MGI: 2687323 HomoloGene: 134510 GeneCards: CDHR2
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDHR2
Genomic location for CDHR2
Band 5q35.2 Start 176,542,511 bp[1]
End 176,595,974 bp[1]
RNA expression pattern
PBB GE PCLKC 220186 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001171976
NM_017675

NM_001033364

RefSeq (protein)

NP_001165447
NP_060145

NP_001028536

Location (UCSC) Chr 5: 176.54 – 176.6 Mb Chr 5: 54.7 – 54.74 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-24 is a protein that in humans is encoded by the PCDH24 gene.[5][6][7]

This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. The kidney-expressed gene product has a signal peptide, nine cadherin repeat domains and a unique cytoplasmic region. This protocadherin represents a new candidate for tumor suppression.[7]

Interactions[edit]

PCLKC has been shown to interact with MAST2.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000074276 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034918 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270. 
  6. ^ a b Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (Jul 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis. 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771. 
  7. ^ a b "Entrez Gene: PCLKC protocadherin LKC". 

Further reading[edit]