PCLKC

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CDHR2
Identifiers
Aliases CDHR2, PCDH24, PCLKC, cadherin related family member 2
External IDs MGI: 2687323 HomoloGene: 134510 GeneCards: 54825
RNA expression pattern
PBB GE PCLKC 220186 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001171976
NM_017675

NM_001033364

RefSeq (protein)

NP_001165447.1
NP_060145.3

n/a

Location (UCSC) Chr 5: 176.54 – 176.6 Mb Chr 13: 54.7 – 54.74 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-24 is a protein that in humans is encoded by the PCDH24 gene.[1][2][3]

This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. The kidney-expressed gene product has a signal peptide, nine cadherin repeat domains and a unique cytoplasmic region. This protocadherin represents a new candidate for tumor suppression.[3]

Interactions[edit]

PCLKC has been shown to interact with MAST2.[2]

References[edit]

  1. ^ Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270. 
  2. ^ a b Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (Jul 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771. 
  3. ^ a b "Entrez Gene: PCLKC protocadherin LKC". 

Further reading[edit]