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PDIA2

From Wikipedia, the free encyclopedia
PDIA2
Identifiers
AliasesPDIA2, PDA2, PDI, PDIP, PDIR, protein disulfide isomerase family A member 2
External IDsOMIM: 608012; MGI: 1916441; HomoloGene: 55994; GeneCards: PDIA2; OMA:PDIA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006849

NM_001081070

RefSeq (protein)

NP_006840

NP_001074539

Location (UCSC)Chr 16: 0.28 – 0.29 MbChr 17: 26.41 – 26.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein disulfide isomerase family A member 2 is a protein that in humans is encoded by the PDIA2 gene.[5]

Function

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This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185615Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024184Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Protein disulfide isomerase family A member 2". Retrieved 2017-12-20.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.