Peflin

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PEF1
Identifiers
Aliases PEF1, ABP32, PEF1A, penta-EF-hand domain containing 1
External IDs MGI: 1915148 HomoloGene: 56569 GeneCards: PEF1
RNA expression pattern
PBB GE PEF1 217923 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012392

NM_026441

RefSeq (protein)

NP_036524

NP_080717.2
NP_080717

Location (UCSC) Chr 1: 31.63 – 31.64 Mb Chr 4: 130.1 – 130.13 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Peflin is a protein that in humans is encoded by the PEF1 gene.[3][4][5]

PEF1 is a Ca(2+)-binding protein that belongs to the penta-EF hand (PEF) protein family, which includes the calpain small subunit (CAPNS1; MIM 114170), sorcin (SRI; MIM 182520), grancalcin (GCA; MIM 607030), and ALG2 (PDCD6; MIM 601057) (Kitaura et al., 2001).[supplied by OMIM][5]

Interactions[edit]

PEF1 has been shown to interact with PDCD6.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kitaura Y, Watanabe M, Satoh H, Kawai T, Hitomi K, Maki M (Oct 1999). "Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region". Biochem Biophys Res Commun. 263 (1): 68–75. doi:10.1006/bbrc.1999.1189. PMID 10486255. 
  4. ^ Kitaura Y, Satoh H, Takahashi H, Shibata H, Maki M (Mar 2002). "Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions". Arch Biochem Biophys. 399 (1): 12–8. doi:10.1006/abbi.2001.2736. PMID 11883899. 
  5. ^ a b "Entrez Gene: PEF1 penta-EF-hand domain containing 1". 
  6. ^ Kitaura, Y; Matsumoto S; Satoh H; Hitomi K; Maki M (Apr 2001). "Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner". J. Biol. Chem. United States. 276 (17): 14053–8. doi:10.1074/jbc.M008649200. ISSN 0021-9258. PMID 11278427. 

Further reading[edit]