Peflin

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
PEF1
Identifiers
AliasesPEF1, ABP32, PEF1A, penta-EF-hand domain containing 1
External IDsOMIM: 610033 MGI: 1915148 HomoloGene: 56569 GeneCards: PEF1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PEF1
Genomic location for PEF1
Band1p35.2Start31,629,866 bp[1]
End31,644,896 bp[1]
RNA expression pattern
PBB GE PEF1 217923 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012392
NM_001359651

NM_026441

RefSeq (protein)

NP_036524
NP_001346580

NP_080717

Location (UCSC)Chr 1: 31.63 – 31.64 MbChr 4: 130.1 – 130.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peflin is a protein that in humans is encoded by the PEF1 gene.[5][6][7]

PEF1 is a Ca(2+)-binding protein that belongs to the penta-EF hand (PEF) protein family, which includes the calpain small subunit (CAPNS1; MIM 114170), sorcin (SRI; MIM 182520), grancalcin (GCA; MIM 607030), and ALG2 (PDCD6; MIM 601057) (Kitaura et al., 2001).[supplied by OMIM][7]

Interactions[edit]

PEF1 has been shown to interact with PDCD6.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162517 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028779 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kitaura Y, Watanabe M, Satoh H, Kawai T, Hitomi K, Maki M (Oct 1999). "Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region". Biochem Biophys Res Commun. 263 (1): 68–75. doi:10.1006/bbrc.1999.1189. PMID 10486255.
  6. ^ Kitaura Y, Satoh H, Takahashi H, Shibata H, Maki M (Mar 2002). "Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions". Arch Biochem Biophys. 399 (1): 12–8. doi:10.1006/abbi.2001.2736. PMID 11883899.
  7. ^ a b "Entrez Gene: PEF1 penta-EF-hand domain containing 1".
  8. ^ Kitaura, Y; Matsumoto S; Satoh H; Hitomi K; Maki M (Apr 2001). "Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner". J. Biol. Chem. 276 (17): 14053–8. doi:10.1074/jbc.M008649200. ISSN 0021-9258. PMID 11278427.

Further reading[edit]