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PHD finger protein 7

From Wikipedia, the free encyclopedia
PHF7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPHF7, HSPC045, HSPC226, NYD-SP6, PHD finger protein 7
External IDsMGI: 1919088; HomoloGene: 69217; GeneCards: PHF7; OMA:PHF7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278221
NM_016483
NM_173341
NM_001321126
NM_001321127

NM_027949
NM_001360624
NM_001360625

RefSeq (protein)

NP_001265150
NP_001308055
NP_001308056
NP_057567

NP_082225
NP_001347553
NP_001347554

Location (UCSC)Chr 3: 52.41 – 52.42 MbChr 14: 30.96 – 30.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PHD finger protein 7 is a protein that in humans is encoded by the PHF7 gene. [5]

Function

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Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells.

The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000010318Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021902Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PHD finger protein 7". Retrieved 2017-09-05.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.