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Phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Protein PIK3R2 PDB 2KT1.png
Rendering based on PDB 2KT1.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PIK3R2 ; MPPH; MPPH1; P85B; p85; p85-BETA
External IDs OMIM603157 MGI1098772 HomoloGene3687 ChEMBL: 4437 GeneCards: PIK3R2 Gene
RNA expression pattern
PBB GE PIK3R2 207105 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5296 18709
Ensembl ENSG00000105647 ENSMUSG00000031834
UniProt O00459 O08908
RefSeq (mRNA) NM_005027 NM_008841
RefSeq (protein) NP_005018 NP_032867
Location (UCSC) Chr 19:
18.15 – 18.17 Mb
Chr 8:
70.77 – 70.78 Mb
PubMed search [1] [2]

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.[1][2]


PIK3R2 has been shown to interact with FYN,[3] HER2/neu,[3] Epidermal growth factor,[3] Cbl gene,[4][5] PIK3CD,[6] CRKL[7] and Macrophage colony-stimulating factor.[3]


  1. ^ Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, Bernardi F, Rooke L, Waterfield MD (May 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene 7 (4): 789–93. PMID 1314371. 
  2. ^ "Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)". 
  3. ^ a b c d Gout, I; Dhand R; Panayotou G; Fry M J; Hiles I; Otsu M; Waterfield M D (Dec 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". Biochem. J. (ENGLAND) 288 (2): 395–405. ISSN 0264-6021. PMC 1132024. PMID 1334406. 
  4. ^ Lin, H; Martelli M P; Bierer B E (Jan 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". Int. Immunol. (England) 13 (1): 13–22. doi:10.1093/intimm/13.1.13. ISSN 0953-8178. PMID 11133830. 
  5. ^ Hartley, D; Meisner H; Corvera S (Aug 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". J. Biol. Chem. (UNITED STATES) 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. ISSN 0021-9258. PMID 7629144. 
  6. ^ Vanhaesebroeck, B; Welham M J; Kotani K; Stein R; Warne P H; Zvelebil M J; Higashi K; Volinia S; Downward J; Waterfield M D (Apr 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. ISSN 0027-8424. PMC 20722. PMID 9113989. 
  7. ^ Sattler, M; Salgia R; Shrikhande G; Verma S; Pisick E; Prasad K V; Griffin J D (Apr 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". J. Biol. Chem. (UNITED STATES) 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. ISSN 0021-9258. PMID 9092574. 

Further reading[edit]