PIK3R2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Protein PIK3R2 PDB 2KT1.png
Rendering based on PDB 2KT1​.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PIK3R2 ; MPPH; MPPH1; P85B; p85; p85-BETA
External IDs OMIM603157 MGI1098772 HomoloGene3687 ChEMBL: 4437 GeneCards: PIK3R2 Gene
RNA expression pattern
PBB GE PIK3R2 207105 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5296 18709
Ensembl ENSG00000105647 ENSMUSG00000031834
UniProt O00459 O08908
RefSeq (mRNA) NM_005027 NM_008841
RefSeq (protein) NP_005018 NP_032867
Location (UCSC) Chr 19:
18.15 – 18.17 Mb
Chr 8:
70.77 – 70.78 Mb
PubMed search [1] [2]

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.[1][2]

Interactions[edit]

PIK3R2 has been shown to interact with:

Clinical relevance[edit]

PIK3R2 mutations were recently shown to be associated with polymicrogyria.[8]

References[edit]

  1. ^ Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, Bernardi F, Rooke L, Waterfield MD (Apr 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene 7 (4): 789–93. PMID 1314371. 
  2. ^ "Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)". 
  3. ^ Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (Apr 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574. 
  4. ^ Lin H, Martelli MP, Bierer BE (Jan 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830. 
  5. ^ Hartley D, Meisner H, Corvera S (Aug 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. PMID 7629144. 
  6. ^ a b c d Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (Dec 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal 288 (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406. 
  7. ^ Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (Apr 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989. 
  8. ^ "Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study". www.sciencedirect.com. Retrieved 2015-10-30. 

Further reading[edit]

  • Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (Nov 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte Biology 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231. 
  • Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (Dec 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal 288 (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406. 
  • Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (Nov 1990). "Purification and characterization of phosphoinositide 3-kinase from rat liver". The Journal of Biological Chemistry 265 (32): 19704–11. PMID 2174051. 
  • Truitt KE, Hicks CM, Imboden JB (Mar 1994). "Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells". The Journal of Experimental Medicine 179 (3): 1071–6. doi:10.1084/jem.179.3.1071. PMC 2191424. PMID 7509360. 
  • Herbst R, Shearman MS, Jallal B, Schlessinger J, Ullrich A (May 1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro". Biochemistry 34 (17): 5971–9. doi:10.1021/bi00017a026. PMID 7537096. 
  • Craparo A, O'Neill TJ, Gustafson TA (Jun 1995). "Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor". The Journal of Biological Chemistry 270 (26): 15639–43. doi:10.1074/jbc.270.26.15639. PMID 7541045. 
  • He W, O'Neill TJ, Gustafson TA (Oct 1995). "Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains". The Journal of Biological Chemistry 270 (40): 23258–62. doi:10.1074/jbc.270.40.23258. PMID 7559478. 
  • Kapeller R, Toker A, Cantley LC, Carpenter CL (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". The Journal of Biological Chemistry 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. PMID 7592789. 
  • Hartley D, Meisner H, Corvera S (Aug 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. PMID 7629144. 
  • Pandey A, Lazar DF, Saltiel AR, Dixit VM (Dec 1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". The Journal of Biological Chemistry 269 (48): 30154–7. PMID 7982920. 
  • August A, Dupont B (May 1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase". International Immunology 6 (5): 769–74. doi:10.1093/intimm/6.5.769. PMID 8080844. 
  • Fukazawa T, Miyake S, Band V, Band H (Jun 1996). "Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins". The Journal of Biological Chemistry 271 (24): 14554–9. doi:10.1074/jbc.271.24.14554. PMID 8662998. 
  • Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (Sep 1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". The Journal of Biological Chemistry 271 (38): 22961–4. doi:10.1074/jbc.271.38.22961. PMID 8798481. 
  • Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (Apr 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574. 
  • Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (Apr 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989. 
  • Briand G, Barbeau B, Tremblay M (Feb 1997). "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase". Virology 228 (2): 171–9. doi:10.1006/viro.1996.8399. PMID 9123823. 
  • Braunger J, Schleithoff L, Schulz AS, Kessler H, Lammers R, Ullrich A, Bartram CR, Janssen JW (Jun 1997). "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site". Oncogene 14 (22): 2619–31. doi:10.1038/sj.onc.1201123. PMID 9178760. 
  • Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP, Siddle K, Zierath JR, Wallberg-Henriksson H (Jul 1997). "Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle". The Journal of Biological Chemistry 272 (30): 19000–7. doi:10.1074/jbc.272.30.19000. PMID 9228082. 
  • Mazerolles F, Barbat C, Fischer A (Sep 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". European Journal of Immunology 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID 9341793.