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PLXNA2

From Wikipedia, the free encyclopedia
PLXNA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLXNA2, OCT, PLXN2, plexin A2
External IDsOMIM: 601054; MGI: 107684; HomoloGene: 56427; GeneCards: PLXNA2; OMA:PLXNA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_025179

NM_008882

RefSeq (protein)

NP_079455

NP_032908

Location (UCSC)Chr 1: 208.02 – 208.24 MbChr 1: 194.3 – 194.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.[5][6]

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.[6]

In some studies, the PLXNA2 gene is associated with schizophrenia.[7] and anxiety. PLXNA2 is a candidate gene for intellectual disability and possibly facial dysmorphism and congenital heart disease[8][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076356Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026640Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci USA. 93 (2): 674–8. Bibcode:1996PNAS...93..674M. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
  6. ^ a b "Entrez Gene: PLXNA2 plexin A2".
  7. ^ "Gene Overview of All Published Schizophrenia-Association Studies for PLXNA2". Schizophrenia Research Forum. Archived from the original on 21 February 2009.
  8. ^ Altuame FD, Shamseldin HE, Albatti TH, Hashem M, Ewida N, Abdulwahab F, Alkuraya FS (July 2021). "PLXNA2 as a candidate gene in patients with intellectual disability". American Journal of Medical Genetics. Part A. 185 (12): 3859–3865. doi:10.1002/ajmg.a.62440. PMID 34327814. S2CID 236516392.
  9. ^ Wray NR, James MR, Mah SP, Nelson M, Andrews G, Sullivan PF, et al. (March 2007). "Anxiety and comorbid measures associated with PLXNA2". Archives of General Psychiatry. 64 (3): 318–26. doi:10.1001/archpsyc.64.3.318. PMID 17339520.

Further reading

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