PLXNA2

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
PLXNA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLXNA2, OCT, PLXN2, plexin A2
External IDsOMIM: 601054 MGI: 107684 HomoloGene: 56427 GeneCards: PLXNA2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PLXNA2
Genomic location for PLXNA2
Band1q32.2Start208,022,242 bp[1]
End208,244,320 bp[1]
RNA expression pattern
PBB GE PLXNA2 gnf1h09338 s at fs.png

PBB GE PLXNA2 207290 at fs.png

PBB GE PLXNA2 213030 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_025179

NM_008882

RefSeq (protein)

NP_079455

NP_032908

Location (UCSC)Chr 1: 208.02 – 208.24 MbChr 1: 194.62 – 194.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.[5][6]

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.[6]

In some studies, the PLXNA2 gene is associated with schizophrenia.[7] and anxiety.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076356 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026640 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci USA. 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111Freely accessible. PMID 8570614. 
  6. ^ a b "Entrez Gene: PLXNA2 plexin A2". 
  7. ^ Gene Overview of All Published Schizophrenia-Association Studies for PLXNA2 Archived 2009-02-21 at the Wayback Machine. - база данных SZGene, сайт Schizophrenia Research Forum
  8. ^ Wray NR, James MR, Mah SP, Nelson M, Andrews G, Sullivan PF, Montgomery GW, Birley AJ, Braun A, Martin NG (March 2007). "Anxiety and comorbid measures associated with PLXNA2". Arch. Gen. Psychiatry. 64 (3): 318–26. doi:10.1001/archpsyc.64.3.318. PMID 17339520. [permanent dead link]

Further reading[edit]