PLXNA2

PLXNA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3Q3J
Identifiers
Aliases	PLXNA2, OCT, PLXN2, plexin A2
External IDs	OMIM: 601054; MGI: 107684; HomoloGene: 56427; GeneCards: PLXNA2; OMA:PLXNA2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	208,244,384 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	194,499,177 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; body of pancreas; ; right lung; ; upper lobe of left lung; ; left ovary; ; right hemisphere of cerebellum; ; right ovary; ; postcentral gyrus; ; left coronary artery; ; right coronary artery;
	Top expressed in
	ganglionic eminence; ; Rostral migratory stream; ; medial ganglionic eminence; ; olfactory tubercle; ; hair follicle; ; lateral septal nucleus; ; nucleus accumbens; ; internal carotid artery; ; ventromedial nucleus; ; external carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; semaphorin receptor activity; identical protein binding;
Cellular component	integral component of membrane; plasma membrane; semaphorin receptor complex; membrane; integral component of plasma membrane;
Biological process	somitogenesis; cell surface receptor signaling pathway; regulation of axon extension involved in axon guidance; cerebellar granule cell precursor tangential migration; branchiomotor neuron axon guidance; limb bud formation; neural tube development; semaphorin-plexin signaling pathway; signal transduction; pharyngeal system development; centrosome localization; regulation of cell migration; negative regulation of cell adhesion; regulation of cell shape; regulation of GTPase activity; positive regulation of axonogenesis; semaphorin-plexin signaling pathway involved in axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	5362
	18845
	ENSG00000076356
	ENSMUSG00000026640
	O75051
	P70207
	NM_025179
	NM_008882
	NP_079455
	NP_032908
	Wikidata
View/Edit Human	View/Edit Mouse

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.^[5]^[6]

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.^[6]

In some studies, the PLXNA2 gene is associated with schizophrenia.^[7] and anxiety.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076356 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026640 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci USA. 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
^ ^a ^b "Entrez Gene: PLXNA2 plexin A2".
^ Gene Overview of All Published Schizophrenia-Association Studies for PLXNA2 - база данных SZGene, сайт Schizophrenia Research Forum
^ Wray NR, James MR, Mah SP, Nelson M, Andrews G, Sullivan PF, Montgomery GW, Birley AJ, Braun A, Martin NG (March 2007). "Anxiety and comorbid measures associated with PLXNA2". Arch. Gen. Psychiatry. 64 (3): 318–26. doi:10.1001/archpsyc.64.3.318. PMID 17339520.

References

Further reading