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porcupine homolog (Drosophila)
Symbol PORCN
Entrez 64840
HUGO 17652
OMIM 300651
RefSeq NM_022825
UniProt Q9H237
Other data
Locus Chr. X p11.23

PORCN (porcupine homolog – Drosophila) is a human gene.[1][2] The protein is homologous to other membrane-bound O-acyltransferases.


The protein encoded by this gene an endoplasmic reticulum transmembrane protein involved in processing of wingless proteins such as WNT7A.[2]

Clinical significance[edit]

Mutations in this gene are associated with focal dermal hypoplasia.[3]

Mutations in PORCN are associated to Goltz-Gorlin syndrome .[4]



  • WNT974 (LGK-974) - 1243244-14-5, researched for anti-cancer effects in Wnt-pathway sensitive tumours.[5] Also investigated for influencing cardiac tissue remodelling following infarction.[6]

IWP (1-4)



  1. ^ Tanaka K, Okabayashi K, Asashima M, Perrimon N, Kadowaki T (July 2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835. 
  2. ^ a b Caricasole A, Ferraro T, Rimland JM, Terstappen GC (April 2002). "Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine". Gene. 288 (1–2): 147–57. doi:10.1016/S0378-1119(02)00467-5. PMID 12034504. 
  3. ^ Wang X, Reid Sutton V, Omar Peraza-Llanes J, et al. (July 2007). "Mutations in X-linked PORCN, a putative regulator of Wnt signaling, cause focal dermal hypoplasia". Nat. Genet. 39 (7): 836–8. doi:10.1038/ng2057. PMID 17546030. 
  4. ^ Brady, P. D.; Van Esch, H; Fieremans, N; Froyen, G; Slavotinek, A; Deprest, J; Devriendt, K; Vermeesch, J. R. (2014). "Expanding the phenotypic spectrum of PORCN variants in two males with syndromic microphthalmia". European Journal of Human Genetics. 23: 551–4. doi:10.1038/ejhg.2014.135. PMC 4666577Freely accessible. PMID 25026905. 
  5. ^ Boone JD, Arend RC, Johnston BE, Cooper SJ, Gilchrist SA, Oelschlager DK, Grizzle WE, McGwin G Jr, Gangrade A, Straughn JM Jr, Buchsbaum DJ (Feb 2016). "Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974". Lab Invest. 96 (2): 249–59. doi:10.1038/labinvest.2015.150. PMID 26658453. 
  6. ^ Moon J, et al. (2017). "Blockade to Pathological Remodeling of Infarcted Heart Tissue Using a Porcupine Antagonist". Proc Natl Acad Sci U S A. 114: 1649–1654. doi:10.1073/pnas.1621346114. PMC 5320972Freely accessible. PMID 28143939.