PPIL1

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PPIL1
Protein PPIL1 PDB 1xwn.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PPIL1, CYPL1, PPIase, hCyPX, CGI-124, peptidylprolyl isomerase like 1
External IDs MGI: 1916066 HomoloGene: 9367 GeneCards: PPIL1
RNA expression pattern
PBB GE PPIL1 gnf1h00200 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016059

NM_026845

RefSeq (protein)

NP_057143

NP_081121.1
NP_081121

Location (UCSC) Chr 6: 36.85 – 36.88 Mb Chr 17: 29.25 – 29.26 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 1 is an enzyme that in humans is encoded by the PPIL1 gene.[3][4][5]

This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mann SS, Pettenati MJ, von Kap-herr C, Hart TC (Mar 1999). "Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (3-4): 228–9. doi:10.1159/000015186. PMID 10072585. 
  4. ^ Ozaki K, Fujiwara T, Kawai A, Shimizu F, Takami S, Okuno S, Takeda S, Shimada Y, Nagata M, Watanabe T, Takaichi A, Takahashi E, Nakamura Y, Shin S (Jan 1997). "Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet. 72 (2-3): 242–5. doi:10.1159/000134199. PMID 8978786. 
  5. ^ a b "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1". 

Further reading[edit]