PPM1D

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PPM1D
Identifiers
Aliases PPM1D, PP2C-DELTA, WIP1, protein phosphatase, Mg2+/Mn2+ dependent 1D, IDDGIP
External IDs MGI: 1858214 HomoloGene: 31185 GeneCards: PPM1D
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for PPM1D
Genomic location for PPM1D
Band 17q23.2 Start 60,600,183 bp[1]
End 60,666,280 bp[1]
RNA expression pattern
PBB GE PPM1D 204566 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003620

NM_016910

RefSeq (protein)

NP_003611

NP_058606

Location (UCSC) Chr 17: 60.6 – 60.67 Mb Chr 17: 85.31 – 85.35 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.[5][6]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.[6]

Interactions[edit]

PPM1D has been shown to interact with CDC5L.[7]

References[edit]

Further reading[edit]