PPP1R13B

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PPP1R13B
Identifiers
AliasesPPP1R13B, ASPP1, p53BP2-like, p85, protein phosphatase 1 regulatory subunit 13B
External IDsMGI: 1336199 HomoloGene: 9090 GeneCards: PPP1R13B
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for PPP1R13B
Genomic location for PPP1R13B
Band14q32.33Start103,733,195 bp[1]
End103,847,590 bp[1]
RNA expression pattern
PBB GE PPP1R13B 216347 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015316

NM_011625

RefSeq (protein)

NP_056131

NP_035755

Location (UCSC)Chr 14: 103.73 – 103.85 MbChr 12: 111.83 – 111.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.[5][6]

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000088808 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021285 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. ^ a b "Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B".

Further reading[edit]