From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein PPP5C PDB 1a17.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PPP5C, PP5, PPP5, PPT, protein phosphatase 5 catalytic subunit
External IDs MGI: 102666 HomoloGene: 4550 GeneCards: PPP5C
RNA expression pattern
PBB GE PPP5C 201979 s at fs.png

PBB GE PPP5C 215705 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 46.35 – 46.39 Mb Chr 7: 17 – 17.03 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene.[3][4]

Model organisms[edit]

Model organisms have been used in the study of PPP5C function. A conditional knockout mouse line, called Ppp5ctm1a(EUCOMM)Wtsi[14][15] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[16][17][18]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[12][19] Twenty five tests were carried out on mutant mice and five significant abnormalities were observed.[12] Homozygous mutant males had decreased body weight, body length and respiratory quotient. Both sexes had increased T cell numbers and a range of skeletal abnormalities identified by radiography.[12]


PPP5C has been shown to interact with ASK1,[20] CRY2[21] GNA12.[22] and Rac1,[23]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yong WH, Ueki K, Chou D, Reeves SA, von Deimling A, Gusella JF, Mohrenweiser HW, Buckler AJ, Louis DN (Sep 1995). "Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3". Genomics. 29 (2): 533–6. doi:10.1006/geno.1995.9972. PMID 8666404. 
  4. ^ "Entrez Gene: PPP5C Protein phosphatase 5, catalytic subunit". 
  5. ^ "Body weight data for Ppp5c". Wellcome Trust Sanger Institute. 
  6. ^ "Dysmorphology data for Ppp5c". Wellcome Trust Sanger Institute. 
  7. ^ "Indirect calorimetry data for Ppp5c". Wellcome Trust Sanger Institute. 
  8. ^ "DEXA data for Ppp5c". Wellcome Trust Sanger Institute. 
  9. ^ "Radiography data for Ppp5c". Wellcome Trust Sanger Institute. 
  10. ^ "Peripheral blood lymphocytes data for Ppp5c". Wellcome Trust Sanger Institute. 
  11. ^ "Citrobacter infection data for Ppp5c". Wellcome Trust Sanger Institute. 
  12. ^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  13. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  14. ^ "International Knockout Mouse Consortium". 
  15. ^ "Mouse Genome Informatics". 
  16. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750. 
  17. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  18. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  19. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837Freely accessible. PMID 21722353. 
  20. ^ Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov 2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". The EMBO Journal. 20 (21): 6028–36. doi:10.1093/emboj/20.21.6028. PMC 125685Freely accessible. PMID 11689443. 
  21. ^ Zhao S, Sancar A (Nov 1997). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity". Photochemistry and Photobiology. 66 (5): 727–31. doi:10.1111/j.1751-1097.1997.tb03214.x. PMID 9383998. 
  22. ^ Yamaguchi Y, Katoh H, Mori K, Negishi M (Aug 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367. 
  23. ^ Chatterjee A, Wang L, Armstrong DL, Rossie S (Feb 2010). "Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro". The Journal of Biological Chemistry. 285 (6): 3872–82. doi:10.1074/jbc.M109.088427. PMC 2823530Freely accessible. PMID 19948726. 

Further reading[edit]