PPRC1

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PPRC1
Identifiers
AliasesPPRC1, PRC, peroxisome proliferator-activated receptor gamma, coactivator-related 1, PPARG related coactivator 1
External IDsMGI: 2385096 HomoloGene: 9006 GeneCards: PPRC1
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PPRC1
Genomic location for PPRC1
Band10q24.32Start102,132,994 bp[1]
End102,150,333 bp[1]
RNA expression pattern
PBB GE PPRC1 203737 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001288727
NM_001288728
NM_015062

NM_001081214
NM_145504
NM_001346801

RefSeq (protein)

NP_001275656
NP_001275657
NP_055877

NP_001074683
NP_001333730

Location (UCSC)Chr 10: 102.13 – 102.15 MbChr 19: 46.04 – 46.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.[5][6][7]

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.[7]

Interactions[edit]

PPRC1 has been shown to interact with USF2.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148840 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055491 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  6. ^ Andersson U, Scarpulla RC (May 2001). "PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells". Mol Cell Biol. 21 (11): 3738–49. doi:10.1128/MCB.21.11.3738-3749.2001. PMC 87014. PMID 11340167.
  7. ^ a b "Entrez Gene: PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1".
  8. ^ Moore, Meredith L; Park Edwards A; McMillin Jeanie B (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". J. Biol. Chem. United States. 278 (19): 17263–8. doi:10.1074/jbc.M210486200. ISSN 0021-9258. PMID 12611894.

Further reading[edit]