PRCP

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PRCP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRCP, HUMPCP, PCP, prolylcarboxypeptidase
External IDsMGI: 1919711 HomoloGene: 55867 GeneCards: PRCP
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PRCP
Genomic location for PRCP
Band11q14.1Start82,822,936 bp[1]
End82,970,584 bp[1]
RNA expression pattern
PBB GE PRCP 201494 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005040
NM_199418
NM_001319214

NM_028243

RefSeq (protein)

NP_001306143
NP_005031
NP_955450

NP_082519

Location (UCSC)Chr 11: 82.82 – 82.97 MbChr 7: 92.87 – 92.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysosomal Pro-X carboxypeptidase is an enzyme that in humans is encoded by the PRCP gene.[5][6]

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137509 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061119 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Tan F, Morris PW, Skidgel RA, Erdos EG (Sep 1993). "Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families". J Biol Chem. 268 (22): 16631–8. PMID 8344943.
  6. ^ a b "Entrez Gene: PRCP prolylcarboxypeptidase (angiotensinase C)".

Further reading[edit]