PRELP

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
PRELP
Identifiers
AliasesPRELP, MST161, MSTP161, SLRR2A, proline/arginine-rich end leucine-rich repeat protein, proline and arginine rich end leucine rich repeat protein
External IDsMGI: 2151110 HomoloGene: 2041 GeneCards: PRELP
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PRELP
Genomic location for PRELP
Band1q32.1Start203,475,828 bp[1]
End203,491,352 bp[1]
RNA expression pattern
PBB GE PRELP 204223 at fs.png

PBB GE PRELP 37022 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_201348
NM_002725

NM_054077

RefSeq (protein)

NP_002716
NP_958505

NP_473418

Location (UCSC)Chr 1: 203.48 – 203.49 MbChr 1: 133.91 – 133.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prolargin is a protein that in humans is encoded by the PRELP gene.[5]

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson–Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188783 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041577 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: PRELP proline/arginine-rich end leucine-rich repeat protein".

Further reading[edit]