PRKAR1B

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PRKAR1B
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRKAR1B, PRKAR1, protein kinase cAMP-dependent type I regulatory subunit beta
External IDs MGI: 97759 HomoloGene: 37665 GeneCards: PRKAR1B
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for PRKAR1B
Genomic location for PRKAR1B
Band 7p22.3 Start 549,197 bp[1]
End 727,650 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253890
NM_008923

RefSeq (protein)

NP_001240819
NP_032949

Location (UCSC) Chr 7: 0.55 – 0.73 Mb Chr 7: 139.02 – 139.15 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.[5][6][7]

Clinical significance[edit]

Mutations in PRKAR1B cause neurodegenerative disorder .[8]

Interactions[edit]

PRKAR1B has been shown to interact with AKAP1[9] and PRKAR1A.[9][10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188191 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025855 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A (Dec 1992). "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7". Genomics. 14 (1): 63–9. doi:10.1016/S0888-7543(05)80284-8. PMID 1358799. 
  6. ^ Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T (Dec 1987). "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis". Am J Hum Genet. 41 (5): 925–32. PMC 1684338Freely accessible. PMID 3479018. 
  7. ^ "Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta". 
  8. ^ Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J (2014). "PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology". Brain. 137 (Pt 5): 1361–73. doi:10.1093/brain/awu067. PMID 24722252. 
  9. ^ a b Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056. 
  10. ^ Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (Oct 1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. PMID 8407966. 

Further reading[edit]