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PRM2

From Wikipedia, the free encyclopedia
PRM2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRM2, CT94.2, protamine 2
External IDsOMIM: 182890; MGI: 97766; GeneCards: PRM2; OMA:PRM2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286356
NM_001286357
NM_001286358
NM_001286359
NM_002762

NM_008933

RefSeq (protein)

NP_001273285
NP_001273286
NP_001273287
NP_001273288
NP_002753

NP_032959

Location (UCSC)Chr 16: 11.28 – 11.28 MbChr 16: 10.61 – 10.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protamine 2 is a protein that in humans is encoded by the PRM2 gene.[5]

Function

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Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus.

Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122304Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038015Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Protamine 2". Retrieved 2020-03-17.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.