PUS1

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PUS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPUS1, MLASA1, pseudouridylate synthase 1
External IDsMGI: 1929237 HomoloGene: 5931 GeneCards: PUS1
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for PUS1
Genomic location for PUS1
Band12q24.33Start131,929,200 bp[1]
End131,945,896 bp[1]
RNA expression pattern
PBB GE PUS1 218670 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002019
NM_001002020
NM_025215

RefSeq (protein)

NP_001002019
NP_001002020
NP_079491

Location (UCSC)Chr 12: 131.93 – 131.95 MbChr 5: 110.77 – 110.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA pseudouridine synthase A is an enzyme that in humans is encoded by the PUS1 gene.[5][6]

PUS1 converts uridine into pseudouridine after the nucleotide has been incorporated into RNA. Pseudouridine may have a functional role in tRNAs and may assist in the peptidyl transfer reaction of rRNAs (Chen and Patton, 1999).[supplied by OMIM][6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177192 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029507 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Chen J, Patton JR (Apr 1999). "Cloning and characterization of a mammalian pseudouridine synthase". RNA. 5 (3): 409–19. doi:10.1017/S1355838299981591. PMC 1369769. PMID 10094309.
  6. ^ a b "Entrez Gene: PUS1 pseudouridylate synthase 1".

Further reading[edit]