Peflin

PEF1
Identifiers
Aliases	PEF1, ABP32, PEF1A, penta-EF-hand domain containing 1
External IDs	OMIM: 610033; MGI: 1915148; HomoloGene: 56569; GeneCards: PEF1; OMA:PEF1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	31,644,896 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	130,021,928 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; ascending aorta; ; skin of leg; ; skin of abdomen; ; popliteal artery; ; tibial arteries; ; Descending thoracic aorta; ; right coronary artery; ; left coronary artery;
	Top expressed in
	granulocyte; ; right kidney; ; duodenum; ; lip; ; facial motor nucleus; ; proximal tubule; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; esophagus; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; protein dimerization activity; metal ion binding; calcium-dependent cysteine-type endopeptidase activity; protein heterodimerization activity; RNA binding; calcium-dependent protein binding; molecular adaptor activity;
Cellular component	cytoplasm; extracellular exosome; membrane; Golgi membrane; COPII vesicle coat; Cul3-RING ubiquitin ligase complex; endoplasmic reticulum; ER to Golgi transport vesicle membrane; cytoplasmic vesicle;
Biological process	response to calcium ion; proteolysis; endoplasmic reticulum to Golgi vesicle-mediated transport; neural crest formation; neural crest cell development; COPII vesicle coating; positive regulation of protein monoubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	553115
	67898
	ENSG00000162517
	ENSMUSG00000028779
	Q9UBV8
	Q8BFY6
	NM_012392; NM_001359651
	NM_026441
	NP_036524; NP_001346580
	NP_080717
	Wikidata
View/Edit Human	View/Edit Mouse

Peflin is a protein that in humans is encoded by the PEF1 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

PEF1 has been shown to interact with PDCD6.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162517 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028779 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kitaura Y, Watanabe M, Satoh H, Kawai T, Hitomi K, Maki M (Oct 1999). "Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region". Biochem Biophys Res Commun. 263 (1): 68–75. doi:10.1006/bbrc.1999.1189. PMID 10486255.
^ Kitaura Y, Satoh H, Takahashi H, Shibata H, Maki M (Mar 2002). "Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions". Arch Biochem Biophys. 399 (1): 12–8. doi:10.1006/abbi.2001.2736. PMID 11883899.
^ "Entrez Gene: PEF1 penta-EF-hand domain containing 1".
^ Kitaura, Y; Matsumoto S; Satoh H; Hitomi K; Maki M (Apr 2001). "Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner". J. Biol. Chem. 276 (17). United States: 14053–8. doi:10.1074/jbc.M008649200. ISSN 0021-9258. PMID 11278427. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading