Structurally, polyketides are complex organic compounds that are often highly active biologically. Many pharmaceuticals are derived from or inspired by polyketides.
Geldanamycin, a useful antibiotic.
Doxycycline, another important antibiotic.
Erythromycin, an antibiotic.
Aflatoxin B1 one of the most carcinogenic compounds known.
Polyketides are usually biosynthesized through the decarboxylative condensation of malonyl-CoA derived extender units in a similar process to fatty acid synthesis (a Claisen condensation). The polyketide chains produced by a minimal polyketide synthase are often further derivatized and modified into bioactive natural products.
Polyketides are structurally a very diverse family of natural products with diverse biological activities and pharmacological properties. They are broadly divided into three classes: type I polyketides (often macrolides produced by multimodular megasynthases), type II polyketides (often aromatic molecules produced by the iterative action of dissociated enzymes), and type III polyketides (often small aromatic molecules produced by fungal species). Polyketide antibiotics, antifungals, cytostatics, anticholesteremic, antiparasitics, coccidiostats, animal growth promoters and natural insecticides are in commercial use.
- The antibiotic agent doxycycline
|Wikimedia Commons has media related to Polyketides.|
- Huffman J, Gerber R, Du L (2010). "Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins". Biopolymers. 93 (9): 764–776. PMC . PMID 20578001. doi:10.1002/bip.21483.
- Robinson JA (1991). "Polyketide synthase complexes: their structure and function in antibiotic biosynthesis". Philos Trans R Soc Lond B Biol Sci. 332 (1263): 107–114. PMID 1678529. doi:10.1098/rstb.1991.0038.
- Katz, Leonard (1997). "Manipulation of Modular Polyketide Synthases". Chem. Rev. 97: 2557–2576. doi:10.1021/cr960025.
- Brockmann, H.; Henkel, W. (1951). "Pikromycin, ein bitter schmeckendes Antibioticum aus Actinomyceten". ntibiotica aus Actinomyceten. 84: 184–288. doi:10.1002/cber.19510840306.