Proscillaridin

Proscillaridin
Clinical data
Other names	3β-Rhamnosido-14β-hydroxybufa-4,20,22-trienolide
AHFS/Drugs.com	International Drug Names
ATC code	C01AB01 (WHO) ;
Identifiers
	IUPAC name 5-[(3S,8R,9S,10R,13R,14S,17R)-14-Hydroxy- 10,13-dimethyl-3-((2R,3R,4R,5R,6R)-3,4,5-trihydroxy- 6-methyltetrahydro-2H-pyran-2-yloxy)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro- 1H-cyclopenta[a]phenanthren-17-yl]-2H-pyran-2-one;
CAS Number	466-06-8 ;
PubChem CID	5284613;
ChemSpider	4447658 ;
UNII	KC6BL281EN;
ChEMBL	ChEMBL600325 ;
CompTox Dashboard (EPA)	DTXSID5023532 ;
ECHA InfoCard	100.006.702
Chemical and physical data
Formula	C30H42O8
Molar mass	530.650 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C\1O\C=C(/C=C/1)[C@H]2CC[C@@]6(O)[C@]2(C)CC[C@H]5[C@H]6CC/C4=C/[C@@H](O[C@@H]3O[C@H]([C@H](O)[C@@H](O)[C@H]3O)C)CC[C@@]45C;
	InChI InChI=1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19-,20+,21-,22+,24-,25+,26+,27-,28-,29+,30-/m0/s1 ; Key:MYEJFUXQJGHEQK-ALRJYLEOSA-N ;
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Proscillaridin is a cardiac glycoside, a kind of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). It is of the bufanolide type and can be obtained from plants of the genus Scilla and in Drimia maritima (Scilla maritima).^[1]

The aglycone of proscillaridin is scillarenin.

References

^ Kedra, M.; Kedrowa, S. (1968). "Clinical evaluation of Proscillaridin A, a glycoside of Scilla maritima". Polski tygodnik lekarski (Warsaw, Poland : 1960). 23 (19): 714–716. PMID 4876207.

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