Prosolanapyrone-III cycloisomerase

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Prosolanapyrone-III cycloisomerase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Prosolanapyrone-III cycloisomerase (EC, Sol5, SPS, solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cyclosiomerase)) is an enzyme with systematic name prosolanapyrone-III:(-)-solanapyrone A isomerase.[1][2][3] This enzyme catalyses the following chemical reaction

prosolanapyrone III (-)-solanapyrone A

The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone in some fungi.


  1. ^ Kasahara, K.; Miyamoto, T.; Fujimoto, T.; Oguri, H.; Tokiwano, T.; Oikawa, H.; Ebizuka, Y.; Fujii, I. (2010). "Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani". Chembiochem. 11: 1245–1252. doi:10.1002/cbic.201000173. PMID 20486243. 
  2. ^ Katayama, K.; Kobayashi, T.; Oikawa, H.; Honma, M.; Ichihara, A. (1998). "Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction". Biochim. Biophys. Acta. 1384 (2): 387–395. doi:10.1016/s0167-4838(98)00040-5. PMID 9659400. 
  3. ^ Katayama, K.; Kobayashi, T.; Chijimatsu, M.; Ichihara, A.; Oikawa, H. (2008). "Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani". Biosci. Biotechnol. Biochem. 72 (2): 604–607. doi:10.1271/bbb.70600. PMID 18256508. 

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