Terpentedienyl-diphosphate synthase

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Terpentedienyl-diphosphate synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Terpentedienyl-diphosphate synthase (EC, terpentedienol diphosphate synthase, Cyc1, clerodadienyl diphosphate synthase) is an enzyme with systematic name terpentedienyl-diphosphate lyase (decyclizing).[1][2][3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate terpentedienyl diphosphate

This enzyme requires Mg2+.


  1. ^ Dairi T, Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H (October 2001). "Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin". Journal of Bacteriology. 183 (20): 6085–94. doi:10.1128/jb.183.20.6085-6094.2001. PMC 99688Freely accessible. PMID 11567009. 
  2. ^ Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H, Dairi T (October 2002). "Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin". The Journal of Biological Chemistry. 277 (40): 37098–104. doi:10.1074/jbc.m206382200. PMID 12138123. 
  3. ^ Eguchi T, Dekishima Y, Hamano Y, Dairi T, Seto H, Kakinuma K (July 2003). "A new approach for the investigation of isoprenoid biosynthesis featuring pathway switching, deuterium hyperlabeling, and 1H NMR spectroscopy. The reaction mechanism of a novel streptomyces diterpene cyclase". The Journal of Organic Chemistry. 68 (14): 5433–8. doi:10.1021/jo026728a. PMID 12839434. 

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