Protein S deficiency
|Protein S deficiency|
|Classification and external resources|
|Patient UK||Protein S deficiency|
Protein S deficiency is a disorder associated with increased risk of venous thrombosis.Protein S, a vitamin K-dependent physiological anticoagulant, acts as a nonenzymatic cofactor to activate protein C in the degradation of factor Va and factor VIIIa. Decreased (antigen) levels or impaired function of protein S leads to decreased degradation of factor Va and factor VIIIa and an increased propensity to venous thrombosis. Protein S circulates in human plasma in two forms: approximately 60 percent is bound to complement component C4b β-chain while the remaining 40 percent is free, only free protein S has activated protein C cofactor activity[medical citation needed]
- Type I - decreased protein S activity: decreased total protein S levels,as well as decreased free protein S levels
- Type II- decreased in regards to the cofactor activity of the protein
- Type III -decreased protein S activity: decreased free protein S levels (normal total protein S levels)
In terms of the cause of protein S deficiency it can be in inherited via autosomal dominance.A mutation in the PROS1 gene triggers the condition. The cytogenetic location of the gene in question is chromosome 3, specifically 3q11.1 Protein S deficiency can also be acquired due to vitamin K deficiency, treatment with warfarin, liver disease, and acute thrombosis (antiphospholipid antibodies may also be a cause as well)
In regards to the mechanism of protein S deficiency we should start by indicating that,Protein S is principally made in liver cells. Protein S is a cofactor of APC both work to degrade factor V and factor VIII.It has been suggested that Zn2+ might be necessary for Protein S binding to factor Xa.
Mutations in this condition change amino acids, which in turn disrupts blood clotting. Functional protein S is lacking, which normally turns off clotting proteins, this increases risk of blood clots.
- Protein S antigen test
- Coagulation test (prothrombin time test)
- Thrombotic disease investigation
- Factor V Leiden test
Among the possibilities for differential diagnosis of protein S deficiency are- Antiphospholipid syndrome, disseminated intravascular coagulation and antithrombin deficiency (though this list is not exhaustive)
In terms of treatment for protein S deficiency the following are consistent with the management (and administration of) individuals with this condition ( it should be noted that the prognosis for inherited homozygotes is usually in line with a higher incidence of thrombosis for the affected individual):
- "Protein S Deficiency. Learn about Protein S Deficiency | Patient". Patient. Retrieved 2016-10-16.
- "Protein S: Reference Range, Collection and Panels, Interpretation". 2016-06-01.
- "Protein S Deficiency: Background, Pathophysiology, Epidemiology". 2016-05-02.
- Reference, Genetics Home. "PROS1 gene". Genetics Home Reference. Retrieved 16 October 2016.
- "Congenital protein C or S deficiency: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 16 October 2016.
- Reference, Genetics Home. "protein S deficiency". Genetics Home Reference. Retrieved 16 October 2016.
- Ten Kate, M. K.; Van Der Meer, J. (1 November 2008). "Protein S deficiency: a clinical perspective". Haemophilia. 14 (6): 1222–1228. doi:10.1111/j.1365-2516.2008.01775.x. ISSN 1365-2516. Retrieved 16 October 2016.
- "Protein S blood test: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 16 October 2016.
- "Protein S deficiency - Conditions - GTR - NCBI". www.ncbi.nlm.nih.gov. Retrieved 16 October 2016.
- ten Kate M, Mulder R, Platteel M, Brouwer J, van der Steege G, van der Meer J (2006). "Identification of a novel PROS1 c.1113T-->GG frameshift mutation in a family with mixed type I/type III protein S deficiency". Haematologica. 91 (8): 1151–2. PMID 16885060.
- García de Frutos, Pablo; Fuentes-Prior, Pablo; Hurtado, Begoña; Sala, Núria (17 October 2007). "Molecular basis of protein S deficiency". Thrombosis and Haemostasis. 98: 543–56. doi:10.1160/TH07-03-0199. ISSN 0340-6245. PMID 17849042. Retrieved 16 October 2016.
- Wypasek, Ewa; Undas, Anetta (1 August 2016). "Protein C and protein S deficiency - practical diagnostic issues". Advances in Clinical and Experimental Medicine. 22 (4): 459–467. ISSN 1899-5276. PMID 23986205.