RAC3

RAC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C2H, 2G0N, 2IC5, 2OV2, 2QME
Identifiers
Aliases	RAC3, ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), Rac family small GTPase 3
External IDs	OMIM: 602050; MGI: 2180784; HomoloGene: 68433; GeneCards: RAC3; OMA:RAC3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,034,204 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,614,795 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; ganglionic eminence; ; ventricular zone; ; right frontal lobe; ; right testis; ; cingulate gyrus; ; anterior cingulate cortex; ; left testis; ; prefrontal cortex; ; anterior pituitary;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; ventromedial nucleus; ; neural tube; ; secondary oocyte; ; superior frontal gyrus; ; primary visual cortex; ; lateral hypothalamus; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; calcium-dependent protein binding; protein binding; GTPase activity; protein kinase binding;
Cellular component	cytoplasm; filamentous actin; cytosol; cell projection; membrane; growth cone; plasma membrane; neuronal cell body; perinuclear region of cytoplasm; neuron projection; extracellular exosome; cytoskeleton; endomembrane system; cell periphery; lamellipodium; intracellular anatomical structure;
Biological process	intracellular signal transduction; neuromuscular process controlling balance; regulation of neuron maturation; synaptic transmission, GABAergic; cerebral cortex GABAergic interneuron development; positive regulation of substrate adhesion-dependent cell spreading; neuromuscular process; cell projection assembly; regulation of cell morphogenesis; homeostasis of number of cells within a tissue; positive regulation of cell adhesion mediated by integrin; neuron projection development; regulation of small GTPase mediated signal transduction; actin cytoskeleton organization; small GTPase mediated signal transduction; cell morphogenesis; actin filament organization; Rho protein signal transduction; cell migration; positive regulation of actin filament polymerization; actin cytoskeleton reorganization; engulfment of apoptotic cell;
	Sources:Amigo / QuickGO
Orthologs
	5881
	170758
	ENSG00000169750
	ENSMUSG00000018012
	P60763
	P60764
	NM_005052; NM_001316307
	NM_133223
	NP_001303236; NP_005043
	NP_573486
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related C3 botulinum toxin substrate 3 is a protein that in humans is encoded by the RAC3 gene.^[5]

Template:PBB Summary

Interactions

RAC3 has been shown to interact with CIB1^[6] and HNF1A.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169750 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018012 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)".
^ Haataja, Leena; Kaartinen Vesa; Groffen John; Heisterkamp Nora (March 2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. 277 (10). United States: 8321–8. doi:10.1074/jbc.M105363200. ISSN 0021-9258. PMID 11756406. yes {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Soutoglou, E; Papafotiou G; Katrakili N; Talianidis I (April 2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J. Biol. Chem. 275 (17). UNITED STATES: 12515–20. doi:10.1074/jbc.275.17.12515. ISSN 0021-9258. PMID 10777539. yes {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)