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RAD51 paralog B
Symbols RAD51B ; R51H2; RAD51L1; REC2
External IDs OMIM602948 MGI1099436 HomoloGene50190 GeneCards: RAD51B Gene
Species Human Mouse
Entrez 5890 19363
Ensembl ENSG00000182185 ENSMUSG00000059060
UniProt O15315 O35719
RefSeq (mRNA) NM_002877 NM_001252562
RefSeq (protein) NP_002868 NP_001239491
Location (UCSC) Chr 14:
67.82 – 68.73 Mb
Chr 12:
79.3 – 79.51 Mb
PubMed search [1] [2]

DNA repair protein RAD51 homolog 2 is a protein that in humans is encoded by the RAD51L1 gene.[1][2][3]


The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.[3]


RAD51L1 has been shown to interact with RAD51C.[4][5][6]


  1. ^ Rapp UR, Marshall TH (June 1981). "Cell surface receptors for endogenous mouse type C viral glycoproteins and epidermal growth factor: tissue distribution in vivo and possible participation in specific cell-cell interaction". J. Supramol. Struct. 14 (3): 343–52. doi:10.1002/jss.400140308. PMID 6261043.  Check date values in: |year= / |date= mismatch (help)
  2. ^ Rice MC, Smith ST, Bullrich F, Havre P, Kmiec EB (August 1997). "Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7417–22. doi:10.1073/pnas.94.14.7417. PMC 23836. PMID 9207106. 
  3. ^ a b "Entrez Gene: RAD51L1 RAD51-like 1 (S. cerevisiae)". 
  4. ^ Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758. 
  5. ^ Sigurdsson S, Van Komen S, Bussen W, Schild D, Albala JS, Sung P (Dec 2001). "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange". Genes Dev. 15 (24): 3308–18. doi:10.1101/gad.935501. PMC 312844. PMID 11751636. 
  6. ^ Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (March 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692. 

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