RECK

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RECK
Identifiers
AliasesRECK, ST15, reversion inducing cysteine rich protein with kazal motifs
External IDsMGI: 1855698 HomoloGene: 9622 GeneCards: RECK
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for RECK
Genomic location for RECK
Band9p13.3Start36,036,433 bp[1]
End36,124,451 bp[1]
RNA expression pattern
PBB GE RECK 205407 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001316345
NM_001316346
NM_001316347
NM_001316348
NM_021111

NM_016678

RefSeq (protein)

NP_057887

Location (UCSC)Chr 9: 36.04 – 36.12 MbChr 4: 43.88 – 43.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene,[5] thought to be a metastasis suppressor.

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.[5] It is one of the targets of an oncomiR, MIRN21.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122707 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028476 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: RECK reversion-inducing-cysteine-rich protein with kazal motifs".

Further reading[edit]