RECK

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RECK
Identifiers
Aliases RECK, ST15, reversion inducing cysteine rich protein with kazal motifs
External IDs MGI: 1855698 HomoloGene: 9622 GeneCards: 8434
RNA expression pattern
PBB GE RECK 205407 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001316345
NM_001316346
NM_001316347
NM_001316348
NM_021111

NM_016678

RefSeq (protein)

NP_066934.1
NP_001303275.1
NP_001303276.1
NP_001303277.1

NP_057887.2

Location (UCSC) Chr 9: 36.04 – 36.12 Mb Chr 4: 43.88 – 43.94 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene,[1] thought to be a metastasis suppressor.

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.[1] It is one of the targets of an oncomiR, MIRN21.

References[edit]

Further reading[edit]