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Protein REG1A PDB 1lit.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases REG1A, ICRF, P19, PSP, PSPS, PSPS1, PTP, REG, regenerating family member 1 alpha
External IDs MGI: 97895 HomoloGene: 68282 GeneCards: REG1A
RNA expression pattern
PBB GE REG1A 209752 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 79.12 – 79.12 Mb Chr 6: 78.42 – 78.43 Mb
PubMed search [1] [2]
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Lithostathine-1-alpha also known as islet cells regeneration factor (ICRF) or islet of Langerhans regenerating protein (REG) is a protein that in humans is encoded by the REG1A gene.[3][4][5]


This protein is a type I subclass member of the Regenerating protein family. The Reg protein family is a multi protein family grouped into four subclasses, types I, II, III and IV based on the primary structures of the proteins. This protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H (Jun 1990). "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The gene encode protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene". J Biol Chem. 265 (13): 7432–9. PMID 2332435. 
  4. ^ Gharib B, Fox MF, Bartoli C, Giorgi D, Sansonetti A, Swallow DM, Dagorn JC, Berge-lefranc JL (Aug 1993). "Human regeneration protein/lithostathine genes map to chromosome 2p12". Ann Hum Genet. 57 (Pt 1): 9–16. doi:10.1111/j.1469-1809.1993.tb00882.x. PMID 8333731. 
  5. ^ a b "Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)". 

Further reading[edit]