RGS20

RGS20
Identifiers
Aliases	RGS20, RGSZ1, ZGAP1, g(z)GAP, gz-GAP, regulator of G-protein signaling 20, regulator of G protein signaling 20
External IDs	OMIM: 607193; MGI: 1929866; HomoloGene: 2745; GeneCards: RGS20; OMA:RGS20 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	53,959,303 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	5,140,508 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; putamen; ; ventricular zone; ; amygdala; ; ganglionic eminence; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; Brodmann area 9;
	Top expressed in
	supraoptic nucleus; ; substantia nigra; ; olfactory tubercle; ; neural layer of retina; ; ventricular zone; ; nucleus accumbens; ; globus pallidus; ; lateral septal nucleus; ; piriform cortex; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity; GTPase activity;
Cellular component	trans-Golgi network; nucleus; cytoplasm; membrane; plasma membrane; cytoplasmic vesicle;
Biological process	negative regulation of signal transduction; regulation of G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8601
	58175
	ENSG00000147509
	ENSMUSG00000002459
	O76081
	Q9QZB1
	NM_001286673; NM_001286674; NM_001286675; NM_003702; NM_170587
	NM_001177795; NM_001290372; NM_021374
	NP_001273602; NP_001273603; NP_001273604; NP_003693; NP_733466
	NP_001171266; NP_001277301; NP_067349
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

RGS20 has been shown to interact with GNAO1^[8] and GNAZ.^[5]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147509 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002459 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Glick JL, Meigs TE, Miron A, Casey PJ (Nov 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". J Biol Chem. 273 (40): 26008–13. doi:10.1074/jbc.273.40.26008. PMID 9748279.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (Nov 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". J Biol Chem. 273 (40): 26014–25. doi:10.1074/jbc.273.40.26014. PMID 9748280.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: RGS20 regulator of G-protein signalling 20".
^ Pagano, Mario; Jordan J Dedrick; Neves Susana R; Nguyen Tracy; Iyengar Ravi (Jun 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cell. Signal. 20 (6). England: 1190–7. doi:10.1016/j.cellsig.2008.02.008. ISSN 0898-6568. PMC 3107604. PMID 18407463. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Nagahama, Masami; Usui Shihomi; Shinohara Takashi; Yamaguchi Tomohiro; Tani Katsuko; Tagaya Mitsuo (Dec 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". J. Cell Sci. 115 (Pt 23). England: 4483–93. doi:10.1242/jcs.00093. ISSN 0021-9533. PMID 12414994. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading