RNF139

From Wikipedia, the free encyclopedia
Jump to: navigation, search
RNF139
Identifiers
Aliases RNF139, HRCA1, RCA1, TRC8, ring finger protein 139
External IDs MGI: 1923091 HomoloGene: 5222 GeneCards: RNF139
RNA expression pattern
PBB GE RNF139 209510 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007218

NM_175226

RefSeq (protein)

NP_009149

NP_780435.1
NP_780435

Location (UCSC) Chr 8: 124.47 – 124.49 Mb Chr 15: 58.89 – 58.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

RING finger protein 139 is a protein that in humans is encoded by the RNF139 gene.[3][4]

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A. 95 (16): 9572–7. doi:10.1073/pnas.95.16.9572. PMC 21380Freely accessible. PMID 9689122. 
  4. ^ a b "Entrez Gene: RNF139 ring finger protein 139". 

Further reading[edit]